A total of 3 patients met the threshold for severe disease (≥ 2 of the following: ECOG-PS ≥ 2, stage IV renal dysfunction, anasarca and/or ascites and/or pleural/pericardial effusions, Hb ≤ 8 g/dL, pulmonary involvement/interstitial pneumonitis with dyspnea), requiring weekly infusion for 4 weeks along with high-dose steroids [16]. This evidence concerns the gene GSTM1 and Interstitial pneumonitis.