NOTCH4 and metabolic dysfunction-associated steatotic liver disease: Additionally, in these patients, we assessed the expression of four microRNAs (miR-122, miR-4758, miR-188, and miR-1226) that target genes involved in MASLD progression (Figure S7), such as HMGCR,ADORA2A, IL-15, VCAM1, CXCR2, FBXW7 e NOTCH4. MiR-122 is the most well-known and prevalent microRNA in hepatic tissue, considered a key positive regulator of de novo lipogenesis and essential for hepatocyte differentiation and development (Fang et al., 2021[10]).