Meanwhile, in the study of esophageal cancer, apigenin was known as a tumor cell IL-6 transcription inhibitor, which inhibited the transcription and expression of IL-6, thereby inhibiting Eca-109 and Kyse-30 cell proliferation, inducing angiogenesis, and promoting apoptosis of esophageal cancer cell (86). This evidence concerns the gene IL6 and esophageal cancer.