Her clinical profile was notable for multiple comorbidities commonly associated with acromegaly, including: essential hypertension, for which she was on antihypertensive medication; chronic heart failure secondary to dilated cardiomyopathy (consistent with AHD), managed with diuretics; obstructive sleep apnoea syndrome (OSAS) coupled with chronic pneumopathy due to severe kyphoscoliosis; osteoporosis with a recent low-energy femoral fracture; and type 2 diabetes mellitus (T2DM), managed with basal insulin and the glucagon-like peptide-1 receptor agonist liraglutide. This evidence concerns the gene INS and diabetes mellitus.