Among the potential mechanisms involving notable genes, the following are identified (Figure 3): Methylation at cg19193136 positively associated with ATG16L1 expression and odds of preeclampsia (Supplementary Figure S1); methylation at cg16318349 positively associated with PMVK expression but negatively with odds of preeclampsia (Supplementary Figure S2); methylation at cg08823240 positively associated with odds of preeclampsia but negatively with MAP3K14 expression (Supplementary Figure S3). Here, ATG16L1 is linked to preeclampsia.