EIF2AK3 and steatosis: The hallmark of hepatic IR, increased gluconeogenesis, is a key event in the progression of simple steatosis to NASH and progressive fibrosis (164, 165).The TXA2 receptor (TP) stimulates hepatic IR and steatosis through the Ca2+/CaMKIIγ-PERK-CHOP-TRB3 signaling pathway (166).