BRAF and adenocarcinoma: It primarily affects men and accounts for approximately 2.2 million cases and 1.8 million deaths each year [2,5,6]. According to the 2021 WHO classification [6], the three most prevalent types of lung cancer are adenocarcinoma, SCC, and neuroendocrine cancers. Adenocarcinomas often show positive results for targetable driver mutations, such as those in the epidermal growth factor receptor, anaplastic lymphoma kinase (ALK), B-RAF, and ROS1 genes [7,8]. However, effective screening methods have detected many asymptomatic high-risk patients, particularly in developed countries [9].