SRY and disorder of sexual differentiation: Furthermore, a large-scale epidemiological study in Iran also screened SRY gene status in 46, XX DSD individuals and found that approximately 85% of testicular DSD patients carried a translocated SRY, while the remainder were SRY-negative, prompting investigations into SOX9 upregulation and other autosomal modifiers (Rastari et al., 2025).