Transthyretin (TTR) is a tetrameric proteincomplex that transportsthyroxine and retinol in cerebral spinal fluid and plasma. Wild-type TTR (wtTTR) is intrinsically proneto amyloid formation and is linked to senile systemic amyloidosis,a late-onset amyloidosis that primarily affects individuals over theage of 80.−, ,  In addition, more than 100 naturally occurring TTR mutations havebeen identified, with several pathogenic variants linked to hereditaryamyloid diseases such as cardiomyopathy and polyneuropathy.−, The gene discussed is TTR; the disease is amyloidosis.