Existing studies have shown that meningeal lymphatic vessels clear Aβ protein and tau protein from brain interstitial fluid via CSF drainage, maintaining a balanced neurofunctional environment and supporting brain health in Alzheimer's disease patients [46]; dysfunction of meningeal lymphatic drainage exacerbates α‐syn pathology, promoting the progression of Parkinson's disease [14]; and following subarachnoid hemorrhage, meningeal lymphatic vessels drain extravasated red blood cells from CSF into dCLN, alleviating the severity of subarachnoid hemorrhage [47]. Here, MAPT is linked to Alzheimer disease.