The galectin-3 produced by tumor cells and macrophages blocks CD8+ T cell activation signals and induces T cell apoptosis by interacting with LAG3 on the T cell surface; while FOXP3+ Tregs suppress anti-tumor immunity by secreting various inhibitory cytokines, such as TGF-β, IL-10 and IFN-γ. Here, CD8A is linked to neoplasm.