Aberrant inactivation of the nuclear receptor PPARγ may contribute to the upregulation of key glycolytic enzymes such as Hexokinase 2 (HK2) and Lactate Dehydrogenase A (LDHA), enhancing tumor cell proliferative capacity.Prior to this study, the nuclear receptor NR6A1 had not been investigated in the context of glucose metabolism. Here, HK2 is linked to neoplasm.