HK1 and lung adenocarcinoma: Pearson correlation analysis based on the IHC score (Fig. 6C) revealed that NR6A1 and HK1 were positively correlated (R = 0.6028, P = 0.0004), as were NR6A1 and p-mTOR (R = 0.4301, P = 0.0177).Patients with high NR6A1 expression exhibited a significantly worse 5-year survival rate (43%) compared to those with low HK1 expression (60%) in lung adenocarcinoma, demonstrating an oncogenic role for nr6a1 in lung adenocarcinoma(P = 0.038)(Fig. 4D).