HK1 and lung adenocarcinoma: Figure 2F shown that the expression of HK1 was significantly increased in primary tumor of lung adenocarcinoma compared with normal Lung samples.Furthermore, NR6A1 expression exhibits a positive correlation with HK1 expression in lung adenocarcinoma (R = 0.1, P = 0.0041)(Fig. 2G).Patients with high HK1 expression exhibited a significantly worse 5-year survival rate (40%) compared to those with low HK1 expression (80%) in lung adenocarcinoma, demonstrating an oncogenic role for HK1 in lung adenocarcinoma(P = 0.00064))(Fig. 2H).