Lipid droplet formation can be regulated by hypoxia-inducible factor; for example, MED15-mediated CPT1A activation has been reported to drive hypoxic tumor progression [82], and lipid droplet–mitochondria interactions mediated by PLIN2, a lipid differentiation-related protein, and CPT1A via phosphofructokinase, liver type promote lipid mobilization [83, 84]. This evidence concerns the gene CPT1A and neoplasm.