SPP1 and hepatocellular carcinoma: The developmental or early stage HCC has been associated with VEGFA, growth differentiation factor 15 (GDF-15), regulated upon activation, normal T cell expressed and secreted (RANTES/CCL5), and osteopontin (OPN), while IL-10, macrophage inflammatory protein 3 (MIP-3), and IL-37b are makers of advanced stage of HCC [19, 23].