By analyzing datasets from miRDB, miRTarBase, starBase and TargetScan, miR-27a-5p was found to be a putative target of Pyk2 and also it was reported that miR-27a-5p is organo-protective in sepsis induced ARDS and organ injurious models [26, 27], and therefore, it was chosen for following further experiments. Here, PTK2B is linked to acute respiratory distress syndrome.