This analysis demonstrated that only four serum soluble factors were independently associated with delirium: CXCL1 (odds ratio (OR): 4.80 (95% confidence interval (CI) 1.52–34.8)), p = 0.041), VEGF-A (OR: 3.66 (95% CI 1.55–10.6), p = 0.007), CXCL13 (OR 2.25: (95% CI 1.16–4.85), p = 0.024), and CCL11 (OR: 2.12 (95% CI 1.11–4.64), p = 0.035). Here, VEGFA is linked to delirium.