Finally, as the emergence of the lymphomyeloid-producing HE clusters a1–a2 and the erythromyeloid-producing HE cluster b2–b3 closely correlated with the emergence of respectively cluster p1 and p2 (Fig. 2e), we investigated whether these two progenitor populations show signs of early LMP or EMP commitment based on previously published EMP and LMP gene signatures (Fig. 4g and Supplementary Table 1). Here, MAEA is linked to hereditary elliptocytosis.