MICB and melanoma: Interestingly, mice that were inoculated intravenously with a melanoma cell line that formed metastases in the lungs (B16F10) or an acute myeloid leukemia cell line that engrafted in the blood and bone marrow (C1498-MICB), or inoculated subcutaneously with a mouse lung cancer cell line (LLC1) had higher serum CD16a/b levels (Fig. 4A).