Age‐associated B cells (ABCs; also termed atypical memory B cells) accumulate during chronic infection and autoimmunity, are frequently T‐bet+CXCR3+, and follow CXCL9/10/11 gradients.3 Although epidemiology and serology strongly link EBV infection to MS, the route by which infected B cells gain CNS access and recruit pathogenic T cells remains unresolved.3,4. The gene discussed is CXCR3; the disease is Epstein-Barr virus infection.