Although other genes (e.g., TM7SF2, LBR, and MVD) harbored three different rare variants in the cohort, they were not prioritized for functional studies, as they were nonrecurrent and their knockout animal models do not exhibit cardiovascular phenotypes relevant to CHD,20–22 precluding their suitability for mechanistic studies or knock-in model construction. The gene discussed is MVD; the disease is coronary artery disorder.