Lower concentrations of synapse-related proteins, such as neuroblastoma suppressor of tumourigenicity, thy-1 membrane glycoprotein, neuronal cell adhesion molecule, tumour necrosis factor receptor super family member 21, neurocan core protein and brevian core protein in CSF have, however, been demonstrated in a study of 15 patients with infection and delirium, compared with patients with infection and no delirium.21 This evidence concerns the gene NCAN and delirium.