The findings demonstrated that activation of α7‐nAChR in the A549 cell lines led to a downstream activation of β‐arrestin which activated the Src kinase and would then cross‐intersect with other mitogenic signaling modules such as PI3 kinase/Akt, Rb‐Raf, and MAPK leading to cancer proliferation in cells [34, 75, 103]. This evidence concerns the gene CHRNA7 and cancer.