In the GSE120495 dataset, the ROC curve showed that ARHGAP9, CD3G, ISG20, SFN, and VSIG4 also had high specificity and sensitivity for renal fibrosis, with AUC values of 0.88, 0.84, 0.92, 1, and 0.96, respectively, and the combined AUC value of the five genes was 1 (Fig. 5C‒D). The gene discussed is ISG20; the disease is renal fibrosis.