Fig. 8 presents the time evolution of tumor volume as well as the concentrations CD8+ T cells in the tumor. We compare local to systemic injections for different doses of CAR-T cells. For the analysis, we performed simulations for both control (abnormal vasculature) and anti-VEGF cases (normalized vasculature). It is important to note that in Fig. 8, for the local injection, the number of CAR-T cells (absolute value) was set 5 orders lower than the number of CAR-T cells/cm3 of mouse vascular volume injected systemically. The gene discussed is CD8A; the disease is neoplasm.