FZD7 and colonic neoplasm: Among WNT receptors, the gene frizzled class receptor 7 (FZD7) has garnered significant attention as being upregulated in a broad spectrum of solid tumors (4, 5), including breast cancer (6, –8), ovarian cancer (9, –11), hepatocellular carcinoma (12, , –15), Wilms’ tumor (16), gastric cancers (17, 18), pancreatic cancer (19, 20), and colon cancer (21, 22).