SPAST and peripheral neuropathy: Another limitation is that abnormalities in sensory nerve conduction studies might have affected SSEPs; however, since only 2/22 individuals in the study presented peripheral neuropathy, both with complex HSP, and the SSEPs results of the overall HSP and the SPG4 subjects (all with pure HSP and with no evidence of peripheral neuropathy) were similar, it is unlikely that the lack of correction for sensory NCS have influenced the study results in a significant manner.