Next, we examined selected compounds 7, 9, 10, 12–14, with IC50 values ≤150 nM against atleast one DNMT, along with the structurally related prototype 2, for their ability to demethylate an endogenous tumor suppressorgene in a solid cancer model, the colon carcinoma HCT-116 cell line.Compound 10 was chosen for its selectivity toward DNMT3A/3L, while compound 14 was selected for itsDNMT1 selectivity. This evidence concerns the gene DNMT3A and colon carcinoma.