Additionally, 2 was 2-fold less cytotoxic in peripheral blood mononuclearcells, used as a model for noncancerous healthy cells. In mouse medulloblastoma stem cells, 2 preferentially inhibited cell growth, while its para/meta regioisomer induced strong cell differentiation. In osteosarcoma (OS) and Ewing sarcoma (EWS), 2 effectively inhibited tumor proliferation in vitro (OS,EWS) and in vivo (OS). Here, EWSR1 is linked to osteosarcoma.