DNMT1 and cancer: Although 3 exhibited weaker DNMT inhibitory activitythan 1 and 2, it demonstrates significantdose- and time-dependent antiproliferative activity in multiple cancercell types, reaching submicromolar concentration. Notably, most of these compounds, including 1–3, not only inhibited DNMT enzymatic activitybut also led to DNMT protein downregulation in various cancer celllines.−,