TP53 and neoplasm: Additionally, 32 alterations (11 for TP53, 6 for RB1, 7 for PTEN, and 8 for CDK12) were exclusive to tumor tissues, whereas 13 alterations (6 for TP53, 3 for RB1, 3 for PTEN, and 1 for CDK12) were unique to ctDNA.