In the current study, we explored for the first time Nf-L in neuronally derived EVs of ET patients with resting tremor, and we did not detect significant differences in NDEV Nf-L levels between rET and HC, suggesting either that neuronal damage in rET is limited compared to other disorders or that cerebellar degeneration is not associated with Nf-L release. Here, NEFL is linked to essential thrombocythemia.