Although we showed that MYH9 is a host factor that enhances infection of divergent endocytic viruses, its role in viral infection was first described for HSV-1; Arii et al. proposed that MYH9 functions as a cellular receptor for HSV-1, favoring virus binding and virus-cell fusion at the plasma membrane by directly interacting with the viral gB glycoprotein (15). Here, MYH9 is linked to viral infectious disease.