Variables with numerically higher hazards included an ECOG score of 1 (HR 7.021, P = 0.075), past or current smoking (HR 1.724, P = 0.477), primary tumor location outside the pancreas (HR 1.880, P = 0.561), extensive metastasis (HR 1.556, P = 0.599), Ki-67 ≥55% (HR 1.682, P = 0.555), and receipt of immunotherapy (HR 5.440, P = 0.046), systemic anti-tumor treatment (HR 1.102, P = 0.901), chemotherapy (HR 5.290, P = 0.050), and hypertension (HR 11.968, P = 0.026), as detailed in Table 3. The gene discussed is MKI67; the disease is hypertensive disorder.