Based on our recently published post‐GWAS functional studies (Zhao et al. 2020; Jiang et al. 2022), we demonstrate in the present study that PCBP2 is a transcriptional regulator of p16INK4a, activating cellular senescence in ECs through its specific binding to a functional SNP (fSNP) rs1333046 within the atherosclerosis‐associated CDKN2A/B locus. This evidence concerns the gene PCBP2 and atherosclerosis.