For example, SPHK1+ TAMs induce CD8+ T cell dysfunction and immune evasion in CRC.[12] Paradoxically, a microarray analysis of 159 specimens from Crohn's‐like colorectal cancer patients revealed that higher expression levels of CD68+ TAMs were associated with improved prognosis.[13] These conflicting findings highlight the heterogeneity in the polarization of TAMs, which is modulated by signals such as cytokines and metabolites within the tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.