CD8A and neoplasm: Beyond the cancer cells themselves, the tumor microenvironment (TME) of liver metastases exhibits a highly immunosuppressive phenotype, leading to systemic depletion of antigen‐specific T lymphocytes and facilitating tumor dissemination.[10] Tumor‐associated macrophages (TAMs) comprehensively influence the cellular composition and metabolic characteristics of the TME by producing immunosuppressive cytokines (such as IL‐10 and TGF‐β) that inhibit CD8+ T cell function and by recruiting immunomodulatory cell populations.