Consistent with previous studies, we found that M2 macrophages enhance cancer cell invasiveness; for instance, they activate the CD36‐dependent epithelial–mesenchymal transition (EMT) pathway in CRC, thereby promoting tumor aggression.[38] Additionally, M2 macrophages secrete anti‐inflammatory cytokines such as IL‐10 and TGF‐β, which suppress T cell‐mediated antitumor immunity and disrupt immune cell crosstalk, fostering an immunosuppressive microenvironment.[39] Therefore, M2‐polarized TAMs create a TME that supports tumor growth and amplifies metastasis. The gene discussed is TGFB1; the disease is colorectal carcinoma.