Ubiquitination, as one of the crucial regulatory mechanisms of post‐translational modification (PTM), plays a pivotal role in maintaining cellular protein homeostasis.[22] Previous studies have established that ubiquitination‐mediated degradation of ASS1 is closely associated with CRC progression.[23] Based on existing research evidence, we hypothesize that ZFPL1 may maintain the stability of ASS1 protein through regulating the ubiquitin‐proteasome pathway. This evidence concerns the gene ZFPL1 and colorectal carcinoma.