CD4 and neoplasm: Previous studies show that the differences in gene expression levels across different tissues are normally quite dramatic, but eQTL signals are relatively stable across tissues.[84, 85] Our validation CD4+ T cell expression eQTLs in normal tissue and in tumor cells both showed relatively high concordance between blood and tissue samples, which implies that we can consider using eQTLs in blood to proxy eQTLs in tumor cells to some extent.