For each of the 455 pairs, the time point with largest sum of the absolute differences between each pairs of MR estimates was set as the reference, pair‐wise Z score was estimated between the reference MR effect and the effect at another time point (i.e., MR effects of expression of ADAM15 in TCM at 40 h on breast cancer [set as the reference] were tested against that at 16 h and 5 d respectively). This evidence concerns the gene ADAM15 and breast carcinoma.