To further elucidate the mechanism underlying CTHRC1 facilitating ccRCC metastasis, we conducted Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) enrichment analyses and identified 689 up-regulated and 403 down-regulated differentially expressed genes (DEGs). Here, CTHRC1 is linked to nonpapillary renal cell carcinoma.