While therapies targeting ICP, such as inhibitors of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cluster of differentiation 80 (CD80)/CD86/cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have transformed cancer treatment, increasing evidence suggests that ICPs are also involved in the pathogenesis of cardiovascular diseases, including abdominal aortic aneurysm (AAA) and atherosclerosis.2 This evidence concerns the gene CTLA4 and cardiovascular disorder.