APOE and triple-A syndrome: In our analysis of 10 AAA transcriptomic datasets (Fig. 1A), we observed consistent up-regulation of the inhibitory pairs CD47/signal regulatory protein alpha (Sirpa) and selectin P ligand (Selplg)/V-set immunoregulatory receptor (Vsir), as well as the stimulatory pair TNF superfamily member 14 (Tnfsf14)/TNF receptor superfamily member 14 (Tnfrsf14), particularly at early disease stages (Day 7 of angiotensin II infusion) compared with Day 28 in apolipoprotein E deficient (ApoE−/−) aortas.