GSDME and triple-negative breast carcinoma: It has been shown that in CM cells, clofarabine (Clo) induces GSDME-mediated apoptosis by activating T cell immunity through CCL5 and CXCL10 (Wu et al., 2025), and FAK-mediated phosphorylation of GRB7 plays a key role in triple-negative breast cancer (TNBC) cell migration (Giricz et al., 2012; Han et al., 2000).