First, at the statistical significance level, both genes reached strict multiple testing correction thresholds (FDR<0.05) in both eQTL and pQTL analyses, and showed strong colocalization signals (PSMR-EPS15L1 = 0.032835, PHEIDI-EPS15L1 = 0.33431; PSMR-HGS = 0.008667, PHEIDI-HGS = 0.102417), indicating that their association with CM risk may be driven by shared causal variants. Here, EPS15L1 is linked to cutaneous mastocytosis.