In addition, subjects with bradycardia also demonstrated an accelerated decline in global cognition when compared to RHR 60–69 bpm (Pinteraction = 0.039) on multivariable adjustment for age, sex, education, ApoE4 status, SBP, hypertension, diabetes, rate-limiting mediations, baseline MMSE and cognitive enhancers. Here, APOE is linked to diabetes mellitus.