Compared to RHR 60–69 bpm, RHR ≥70 bpm demonstrated an accelerated decline in global cognition (Pinteraction = 0.035, Table 2) on multivariable adjustment for age, sex, education, ApoE4 status, SBP, history of hypertension, diabetes, rate-limiting medications, baseline MMSE and cognitive enhancers. The gene discussed is APOE; the disease is hypertensive disorder.