Taken together, our findings highlight that the natural history and treatment modalities for paediatric CM are similar to those of adult-onset cases, except for seizure control, which appears to be more favourable in children.20,51 Similarly, our findings on the molecular biology of paediatric CM emphasized the predominance of PIK3CA in the pathogenesis and aggressiveness of CM, as observed in adult-onset cases.12,30 We also confirmed the involvement of MAP3K3 in S-CM in children.32,46. The gene discussed is MAP3K3; the disease is cutaneous mastocytosis.