The dual role of miR-107 in other cancers—suppressing metastasis in breast cancer via neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) (Zhou et al., 2022) yet promoting growth in non-small cell lung cancer (NSCLC) via large tumor suppressor kinase 2/yes-associated protein (LATS2/YAP) (Jin et al., 2020)—highlights the necessity of context-specific validation. The gene discussed is NEDD9; the disease is cancer.