Pten+/− mice also develop lesions not seen in patients with PHTS including, pheochromocytoma and intraepithelial neoplasia (PIN) and adenocarcinoma of the prostate (Knobbe et al., 2008; Di Cristofano et al., 1998, 2001; Suzuki et al., 1998; Podsypanina et al., 1999; Freeman et al., 2006). This evidence concerns the gene PTEN and hereditary pheochromocytoma-paraganglioma.