We used mice on a mixed C57Bl/6JxSv129 background, as on this background Pten+/− mice develop PHTS-relevant phenotypes, with an overlapping tumour spectrum including hyperplasia/tumours of the thyroid, endometrium, lymphoid tissue, small intestine and adenomyoepithelioma, and malignant mammary tumours in the females (Tibarewal et al., 2022). The gene discussed is PTEN; the disease is neoplasm.