These include Pten+/− mice, which represent the heterozygous genetic constellation of PTEN in PHTS and on a mixed C57BL6xSv129 background develop multiple phenotypes overlapping with the clinical presentation of PHTS, including brain and lymphoid overgrowth and the development of specific cancers (Tibarewal et al., 2022). The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.