Pten+/R173C mice developed far fewer tumours than Pten+/− mice, with occasional hyperplasia of the small intestine (2/14 mice) and low-grade PINs of prostate (4/14 mice), one case of mammary adenocarcinoma (1/22 mice) and one case of endometrial hyperplasia (1/28) (Fig. 3B; Figs S11 and S12, Tables S4 and S5). This evidence concerns the gene PTEN and neoplasm.