PTEN and PTEN hamartoma tumor syndrome: For these studies, we used Pten+/− mice, a well-characterised model of PHTS (Knobbe et al., 2008; Di Cristofano et al., 1998, 2001; Suzuki et al., 1998; Podsypanina et al., 1999; Freeman et al., 2006), alongside littermate WT (Pten+/+) mice as controls.