PIK3CA and neoplasm: Another SWATH‐MS proteomics study indicated that colorectal cancer (CRC) patient‐derived organoids (PDOs) accurately reproduced the protein expression features of the patient's tumor, especially key signaling pathways like Wnt, MAPK, and PI3K.[240] Furthermore, drug response experiments elucidated the resistance mechanisms of PDOs and revealed tumor heterogeneity through protein expression differences across various PDOs.