As type H endothelium (CD31+EMCN+) orchestrates osteoprogenitor recruitment and new bone formation,[8, 39] NOX2‐driven EndMT and the attendant ECM remodeling plausibly compromise type H identity and abundance under diabetes, depriving the interface of required vascular support for remodeling/mineralization. The gene discussed is EMCN; the disease is diabetes mellitus.