To determine endothelial NOX2 necessity in the diabetic microenvironment, we generated EC‐specific Nox2 knockout mice (DM–EC‐Nox2−/−) using Cdh5‐Cre crossed to Nox2fl/fl and compared with diabetic littermate controls (DM–EC‐Nox2fl/fl) (Figure 4H). This evidence concerns the gene CDH5 and diabetes mellitus.