CYBB and diabetes mellitus: Histological analyses supported these improvements: H&E showed preservation of trabeculae in DM–EC‐Nox2−/− (Figure 6K); Masson's trichrome demonstrated greater collagen/mineralized matrix in DM–EC‐Nox2−/− both in NM and DM cohorts (NM: 83.92 ± 3.47% vs 73.47 ± 3.05%; DM: 76.76 ± 8.29% vs 32.27 ± 9.47%) (Figure 6L,M); and Van Gieson staining revealed increased newly formed bone near the growth plate in EC‐Nox2−/−, with histomorphometry confirming higher neogenesis in DM (EC‐Nox2−/− > EC‐Nox2fl/fl; NM groups, n.s.)(Figure 6N,O).