Previously, we made the novel discovery that Syntaxin 4 (STX4), traditionally considered a cell surface exocytosis protein in skeletal muscle critical for GLUT4‐vesicle fusion in insulin‐stimulated glucose uptake [18] and downregulated in T2D skeletal muscle, was additionally localized to the outer mitochondrial membrane (OMM) [8]. Here, INS is linked to type 2 diabetes mellitus.