Therefore, TNC has been identified as a multifunctional target for CAR-Ms since it not only can harness the phagocytic ability of CAR-Ms to accelerate the clearance of fibrotic and inflammatory HSCs in liver fibrosis but can also increase the infiltration of M2-polarized macrophages and the activation of CD8+ T cells in the hepatic immune microenvironment. Here, CD8A is linked to Hepatic fibrosis.