The protein expression of α-SMA, Collagen-1, Bax/Bcl-2, and Cleaved Caspase-3/Caspase-3 in liver tissues further supported these observations (Fig. 8A, B), indicating that disruption of BAs homeostasis exacerbated fibrosis in LF model mice. The gene discussed is CASP3; the disease is Lassa fever.