AKT1 and diabetic cardiomyopathy: Hashiesh et al. (2024) found that activation of the CB2 receptor with β-caryophyllene markedly attenuated AGE/RAGE-induced oxidative stress, suppressed TGF-β/Smad-driven fibrosis, enhanced the PI3K/AKT/Nrf2β antioxidant pathway, and inhibited NLRP3 inflammasome activation in diabetic cardiomyopathy [118].