Elevated serum levels of PIIINP, along with Galectin-3 and ST2, have been shown to correlate with impaired left ventricular diastolic function, suggesting their potential as non-invasive surrogates for structural and functional myocardial abnormalities, including myocardial fibrosis as assessed by late gadolinium-enhanced cardiac MRI [73]. The gene discussed is LGALS3; the disease is Myocardial fibrosis.