The expression levels of HK2 and FOXD1 mRNA were both increased in cancer group compared to those in normal group (Supplementary Fig. S1E, F), and HK2 (Table 2) and FOXD1 (Fig. 1B-I) mRNA levels were both increased after hypoxic treatment in prostate cancer PC-3, 22Rv1, DU145, and LNCaP cells. Here, FOXD1 is linked to Familial prostate cancer.