The top 10 marker genes of endothelial subtypes are shown in Fig. 3P. In humans, loss-of-function mutations in VEGFC or VEGFR3 can lead to lymphedema, while the application of recombinant VEGFC can stimulate robust lymphangiogenesis in adults, suggesting its therapeutic potential for lymphedema and tissue repair. This evidence concerns the gene FLT4 and lymphedema.