Bearing this information in mind, several cancer-relevant ChrY loci also encode minor histocompatibility molecules (e.g.,TMSB4Y) [174, 178], are committed surface, tumor-associated molecules such TPSY, influence the expression of others like CD99 [131, 158], or are highly relevant to cancer in terms of contributing to the non-self identification of malignant lesions; as a result, these ChrY-encoded proteins could be good features to either monitor or examine in samples clinically or target with immunotherapy. Here, TMSB4Y is linked to cancer.