In vivo analyses using LoVo cells (colorectal adenocarcinoma) very significantly found that when these KDM5D-overexpressing cells were used in xenografts they produced much smaller tumors which caused way fewer metastatic liver nodules than controls; the latter observation was supported by higher and lower respective relative levels of E-cadherin and vimentin in these cells, a finding that indicates that KDM5D reverses the EMT-induced migratory behavior. The gene discussed is KDM5D; the disease is colorectal adenocarcinoma.