FLI1 and hematologic disorder: Furthermore, in 2019 Terao and colleagues performed a GWAS on 95,380 Japanese men with mLOY which connected this form of aneuploidy to the differential binding of a cell fate-determining factor called Friend Leukemia Virus Integration 1 (FLI1) which ultimately informs the differentiation of hemopoietic stem cells [35]; this is significant because aberrant expression of this this gene is frequently observed in multiple hematological malignancies and malignant transformation [70].