data from the discovery set by this group revealed a total of 11 genes whose expression was significantly affected by LOY in these cancers; among these was the tumor-suppressive, ChrY-encoded epigenome regulator KDM5D as well as histone demethylase, lysine demethylase 6C (KDM6C)/ Ubiquitously-Transcribed Tetratricopeptide Repeat Protein Y-linked (UTY). The gene discussed is KDM5D; the disease is cancer.