Ultimately, this relationship was proven to be biologically relevant by an A549 (lung carcinoma) xenograft model with and without CRISPR/Cas9-mediated KDM5D depletion; when injected subcutaneously KDM5D-deficient cells formed larger tumors than controls as well as forming many more tumor foci in the lungs of mice intravenously injected with these cells, in each case higher fractions of methylated p38ɑ were discovered in the KDM5D-deficient tumor [168]. Here, KDM5D is linked to lung carcinoma.